I was trying out various menu items using 2 propanol as my molecule to see what is working and what is not. . I was using RDkit and when I asked it to UFF optimize the structure, It lost 7 hydrogen and made a unique structure which I am uploading. This is under Fedora 44 Appimage avogadro 2.0.0 and rdkit 0.2.1
I appreciate the bug report – it’s almost certainly an issue with RDKit generally ignoring hydrogen atoms. I don’t think there’s much benefit to using RDKit for UFF optimization though since we already have an implementation.